Peptide Therapy — A Physician's Educational Guide
Dr. Edward S. Rubin, M.D. has partnered with REVRCEL to provide patients with a comprehensive, physician-informed introduction to peptide science.
⚠️ Important: Peptide therapies are not FDA-approved for most wellness and anti-aging indications. All content on this page is strictly educational and does not constitute medical advice, a prescription, or a treatment plan. Dr. Rubin does not prescribe or manage peptide therapy. Patients order directly from REVRCEL's licensed pharmacy partners.
What Are Peptides?
The Science
Peptides are short chains of amino acids (2–50 residues) that act as biological signaling molecules. They bind to specific receptors and trigger targeted physiological responses — from growth hormone secretion and tissue repair to immune modulation and metabolic activation.
Compounding Pharmacy
Most REVRCEL peptides are compounded — prepared by licensed pharmacies to order, not mass-manufactured. Patients order directly from the pharmacy under supervision of their own prescribing physician. Dr. Rubin's role here is educational only.
Regulatory Status
The majority of peptide compounds discussed here are NOT FDA-approved for wellness indications. They remain investigational, with emerging but not fully established evidence. Regulatory status may change at any time without notice.
23 Active Compounds — Full Reference
Available through REVRCEL's physician-guided platform. Filter by category to explore the science behind each compound. Use code RUBIN25 for an exclusive patient discount at checkout.
Exclusive Patient Discount
Dr. Rubin has partnered with REVRCEL to offer his patients an exclusive discount on their physician-guided peptide platform.
Click code to copy · Apply at checkout on revrcel.com
Shop REVRCEL → revrcel.comDr. Rubin does not receive compensation from REVRCEL purchases. Physician-guided, pharmacy-fulfilled. Patients order directly.
AOD-9604
HGH Fat-Burning Fragment
- ·hGH fragment (aa 176–191) — the isolated fat-burning region of growth hormone
- ·Stimulates lipolysis; inhibits lipogenesis without affecting blood sugar or IGF-1
- ·No anabolic activity — safe for long-term metabolic use
BPC-157
Body Protection Compound
- ·15-amino-acid peptide from human gastric juice; stimulates nitric oxide and growth factor pathways
- ·Accelerates healing of muscles, tendons, ligaments, and GI lining
- ·Potent anti-inflammatory; promotes angiogenesis at injury sites
CJC-1295
GHRH Analog — Sustained GH Release
- ·Synthetic GHRH analog; stimulates pituitary GH secretion
- ·DAC form: half-life ~8 days for sustained GH elevation
- ·Most effective stacked with Ipamorelin for synergistic GH output
DSIP
Delta Sleep-Inducing Peptide
- ·9-amino-acid neuropeptide modulating sleep-wake cycles via CNS
- ·Promotes deep/delta slow-wave sleep — the most restorative phase
- ·Reduces cortisol and ACTH spikes that disrupt sleep architecture
Epitalon
Telomere & Pineal Longevity Peptide
- ·Tetrapeptide from the pineal gland; stimulates telomerase activity
- ·Lengthens telomeres and slows cellular aging at the genetic level
- ·Regulates melatonin production for circadian rhythm normalization
GHK-Cu
Copper Tripeptide-1
- ·Naturally occurring copper-binding tripeptide (Gly-His-Lys)
- ·Activates collagen, elastin, and glycosaminoglycan synthesis genes
- ·Upregulates over 4,000 human genes — broadest regenerative footprint in catalog
IGF-1 LR3
Long-Acting Growth Factor Analog
- ·Long-acting IGF-1 analog; half-life ~20–30 hrs vs. 15 min native
- ·Activates satellite cells → direct muscle hypertrophy and new fiber growth
- ·Lab Required — IGF-1 monitoring needed to prevent overstimulation
Ipamorelin
Cleanest GH Secretagogue
- ·Pentapeptide GHRP; mimics ghrelin at pituitary receptors
- ·No cortisol spike, no prolactin increase, no hunger stimulation
- ·Most versatile peptide — stacked with CJC-1295 for maximum GH output
Kisspeptin-10
HPG Axis Hormonal Activator
- ·10-aa neuropeptide activating the hypothalamic-pituitary-gonadal (HPG) axis
- ·Triggers GnRH → LH → FSH → estrogen/testosterone — the master hormonal cascade
- ·Supports women in perimenopause without suppressing the HPG axis
KPV
Alpha-MSH Anti-Inflammatory Fragment
- ·C-terminal tripeptide of α-MSH; binds MC1R and MC3R receptors
- ·Suppresses NF-κB signaling; reduces pro-inflammatory cytokines
- ·Powerful gut-specific anti-inflammatory — non-immunosuppressive
LL-37
Cathelicidin Antimicrobial Peptide
- ·Only cathelicidin produced in humans; broad-spectrum antimicrobial
- ·Disrupts bacterial, fungal, and viral membrane integrity
- ·Anti-biofilm against drug-resistant organisms including MRSA
MOTS-c
Mitochondrial Metabolic Peptide
- ·Encoded in mitochondrial 12S rRNA — the 'exercise mimetic' peptide
- ·Activates AMPK — master metabolic switch for energy homeostasis
- ·Enhances insulin sensitivity, glucose uptake, and mitochondrial biogenesis
NAD+
Cellular Energy Coenzyme
- ·Essential coenzyme in every cell; central to 500+ enzymatic reactions
- ·Activates sirtuins (longevity pathways) and PARP enzymes for DNA repair
- ·Levels decline ~50% by age 60; injectable form for maximum cellular uptake
Oxytocin
The Bonding Hormone
- ·9-amino-acid neuropeptide from the hypothalamus — primary bonding molecule
- ·Promotes trust, empathy, emotional safety, and social closeness
- ·Reduces cortisol; activates the parasympathetic nervous system
PT-141
Bremelanotide — Central Arousal
- ·Melanocortin receptor agonist (MC3R, MC4R); acts in the CNS, not the vascular system
- ·FDA-approved for HSDD in women (Vyleesi); effective in both men and women
- ·Works regardless of hormonal or vascular status — addresses the neural root of desire
Selank
Anxiolytic Neuropeptide
- ·Heptapeptide tuftsin analog; modulates GABA-A and upregulates BDNF
- ·Reduces anxiety without sedation, dependency, or withdrawal risk
- ·Enhances memory consolidation, emotional resilience, and learning
Semax
ACTH Cognitive Analog
- ·Synthetic ACTH(4-7) analog; increases BDNF, NGF, and VEGF expression
- ·Enhances dopaminergic and serotonergic tone for focus and stress resilience
- ·Used clinically in Russia for stroke recovery, cognitive decline, and ADHD
Sermorelin
Physiological GH Stimulator
- ·29-amino-acid GHRH analog; stimulates anterior pituitary to secrete GH
- ·Preserves the pituitary feedback loop — unlike direct HGH injection
- ·Safer long-term alternative to exogenous HGH; quarterly lab monitoring required
TB-500
Thymosin Beta-4 Fragment
- ·Synthetic fragment of Thymosin Beta-4; promotes actin polymerization and tissue remodeling
- ·Potent angiogenic — stimulates new blood vessel formation for healing perfusion
- ·Crosses the blood-brain barrier; neuroprotective; reduces fibrosis and scar formation
Tesamorelin
FDA-Approved GHRH Analog
- ·FDA-approved for HIV-associated lipodystrophy (Egrifta) — clinically validated
- ·Stimulates endogenous GH and IGF-1; measurable visceral adipose tissue reduction
- ·Preserves lean muscle; improves lipid profiles and insulin sensitivity. Lab Required.
Thymosin Alpha-1
T-Cell Immune Modulator
- ·28-amino-acid thymus peptide; promotes Th1 cytokines, dendritic cells, and NK cells
- ·FDA Orphan Drug status; used in 35+ countries for hepatitis B/C, cancer, and sepsis
- ·Immunomodulatory — restores immune balance rather than suppressing it
Semaglutide
GLP-1 Receptor Agonist — Rx Only
- ·Long-acting GLP-1 agonist; regulates appetite and glucose metabolism
- ·FDA-approved: Ozempic (T2D), Wegovy (obesity) — 15–20% body weight reduction in trials
- ·Physician prescription required; weekly subcutaneous injection with dose titration
Tirzepatide
Dual GIP/GLP-1 Agonist — Rx Only
- ·First-in-class dual GIP + GLP-1 receptor agonist; two incretin pathways at once
- ·FDA-approved: Mounjaro (T2D), Zepbound (obesity) — up to 22.5% weight loss in trials
- ·Superior to semaglutide in SURMOUNT head-to-head trials; Rx required
Patient Downloads
Physician-prepared reference materials. Review these before consulting with any prescribing physician.
Peptide Compendium
A 24-slide physician-curated reference deck covering all 23 active compounds — mechanism of action, clinical notes, and product context.
⬇ Download (.pptx)PowerPoint · 24 Slides
Product Formulations
Complete formulation breakdown of every REVRCEL product — ingredients, doses, mechanisms, and a master compound cross-reference table.
⬇ Download (.docx)Word Document · 19 Products
Informed Consent Form
Physician-drafted educational consent covering the experimental nature of peptides, patient autonomy, and direct pharmacy ordering. Sign digitally — a copy is emailed to you and to our office instantly.
✍️ Sign Digitally →E-signature · Emailed to you & our office
⚕ Full Regulatory & Legal Disclaimer
For Educational Purposes Only. All content on this page is provided strictly for informational and educational purposes. Nothing here constitutes medical advice, a diagnosis, a prescription, a treatment plan, or a clinical recommendation. This page does not create a physician-patient relationship between Dr. Edward S. Rubin, M.D. and any visitor.
FDA Status. Most peptide compounds discussed are NOT approved by the U.S. Food and Drug Administration (FDA) for the wellness, anti-aging, or performance indications described. These compounds are investigational. Their safety, efficacy, and long-term effects have not been fully established. Regulatory status may change at any time.
Dr. Rubin's Role. Dr. Rubin provides education only. He does not prescribe, dispense, or manage peptide therapy.
These statements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease. Use code RUBIN25 for a patient discount at revrcel.com.
Questions About Peptide Therapy or Your Pain Treatment?
Call our office or request an appointment online. Most major insurance plans accepted.